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Pragmatic trials are those that are designed to inform real-world clinical practice. They are usually focused on the practical aspects of study design, such as the recruitment and consent process as well as adherence to the use of standard equipment.

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Pragmatic Software, a software firm provides a variety of casino games for online gambling platforms. Its iGaming solutions are used by the top operators and land-based casinos. The company offers front-end design tools, analysis, promotions, marketing and payment systems, as well as security, customer service and bug reporting. Additionally, the company offers its players a safe and secure environment with high-quality graphics and games.

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A practical trial that employs different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for pragmatic trials to be valid and lessen the chance of bias is also essential. A high degree of heterogeneity, however can result in problems with the trial design.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market, provides an array of traditional table games, including Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta provide a genuine gambling experience for customers, as well as a full suite of virtual betting options. The company has also created various interactive games to make online gambling fun. Some of these shows have live hosts, while others are hosted by celebrities from the industry.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually ordered by policymakers and practitioners in order to guide their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, they shouldn't be used to substitute for explanatory trials.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the features of a pragmatic trial, including recruitment, design and delivery of the intervention, as well as the follow-up.

There is an encouraging trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.